A CONVENIENT SYNTHESIS OF 5-DEAZA NONCLASSICAL ANTIFOLATES - REACTION OF CYANOTHIOACETAMIDE WITH SODIUM-SALTS OF 2-(HYDROXYMETHYLENE)-1-CYCLOALKANONES

被引：51

作者：

ELGEMEIE, GEH

HUSSAIN, BAW

机构：

[1] Chemistry Department, Faculty of Science, Qatar university, Doha

来源：

TETRAHEDRON | 1994年 / 50卷 / 01期

关键词：

D O I：

10.1016/S0040-4020(01)80745-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of cyanothioacetamide with sodium salts of 2-(Hydroxymethylene)-1-cycloalkanones afforded the corresponding pyridine-2(1H)-thiones 4. Compounds 4 served as a key intermediates for the synthesis of condensed 2,4-diaminopyrido[2,3-d]pyridines 7. Compounds 7 were of interest as potential inhibitors of dihydrofolate reductase.

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页码：199 / 204

页数：6

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