EPIMERIZATION-FREE PEPTIDE FORMATION FROM CARBOXYLIC-ACID ANHYDRIDES AND AZIDO DERIVATIVES

被引：29

作者：

BOSCH, I ^{[1
]}

URPI, F ^{[1
]}

VILARRASA, J ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC QUIM,DEPT QUIM ORGAN,E-08028 BARCELONA,SPAIN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 01期

关键词：

D O I：

10.1039/c39950000091

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conversion of C-terminal carboxy groups of N-protected alpha-amino acids to the corresponding 3,5-dinitrobenzoyl mixed anhydrides, followed by treatment with alpha-azido eaters and trialkylphosphines, affords good yields of peptides, without appreciable formation of epimers even for reactions involving Phe-Val and Val-Val couplings and/or Nbenroyl alpha-amino acids.

引用

页码：91 / 92

页数：2

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