EVALUATION CONTROL AND PREDICTION OF DRUG DIFFUSION THROUGH POLYMERIC MEMBRANES .I. METHODS REPRODUCIBILITY OF STEADY-STATE DIFFUSION STUDIES

The equipment and methods for the study of drug diffusion through polymeric membranes are described. Among studies conducted on a given day, diffusion rates were reproducible within a coefficient of variation of 3,2 percent. Variation in ionic strength from 0.1‐0.4 and the variations in hydrostatic head studied had no significant effect on the rates of diffusion of 4′‐aminopropiophenone from 6.8 phosphate buffer through silastic membrane into 0.12 N HCl. Silastic membrane is shown to be impermeable to phosphate buffer and hydrogen and chloride ions. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company