EVALUATION CONTROL AND PREDICTION OF DRUG DIFFUSION THROUGH POLYMERIC MEMBRANES .I. METHODS REPRODUCIBILITY OF STEADY-STATE DIFFUSION STUDIES

被引：99

作者：

GARRETT, ER

CHEMBURK.PB

机构：

[1] College of Pharmacy, University of Florida, Gainesville, Florida

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 06期

关键词：

4′‐Aminopropiophenone—diffusion; Diffusion cell; steady state—diagram; Hydrostatic pressure—steady‐state diffusion effect; Ionic strength—steady‐state diffusion effect; Polymeric membranes—drug diffusion; Quasi‐steady‐state diffusion cell—diagram; Silastic membranes—permeability;

D O I：

10.1002/jps.2600570606

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The equipment and methods for the study of drug diffusion through polymeric membranes are described. Among studies conducted on a given day, diffusion rates were reproducible within a coefficient of variation of 3,2 percent. Variation in ionic strength from 0.1‐0.4 and the variations in hydrostatic head studied had no significant effect on the rates of diffusion of 4′‐aminopropiophenone from 6.8 phosphate buffer through silastic membrane into 0.12 N HCl. Silastic membrane is shown to be impermeable to phosphate buffer and hydrogen and chloride ions. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：944 / &