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CHANGES IN TROPOMYOSIN SUBUNIT PATTERN IN CHRONIC ELECTRICALLY STIMULATED RABBIT FAST MUSCLES

被引：37
作者：
ROY, RK
MABUCHI, K
SARKAR, S
MIS, C
SRETER, FA
机构：
[1] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115
[2] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
D O I：
10.1016/0006-291X(79)90961-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tropomyosin subunit ratio of rabbit fast muscle (α:β = 80:20) changes to that characteristic of skeletal slow muscles (α:β = 55:45) on continuous (10 Hz) stimulation for 3 weeks. The altered myosin light chain pattern and histochemical ATPase stain also show clear changes of fast → slow transformation. However, the rate of changes in the light chain patterns of myosin are slower than those of tropomyosin subunits. These results do not support the previous finding (Amphlett et al., Nature 257, 602, 1975) that the tropomyosin subunit pattern remains unaltered during transformation of skeletal muscles and the conclusion that the genetic expression of tropomyosin is regulated under separate control from other myofibrillar proteins. Rather, our results suggest that the polymorphic patterns of all myofibrillar proteins in skeletal muscles undergo changes in a temporal manner during skeletal muscle transformation. © 1979.
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页码：181 / 187
页数：7
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