SYNTHESIS AND ANTIVIRAL PROPERTIES OF NEW CYCLOALKANOL DERIVATIVES OF GUANINE

被引：7

作者：

HALAZY, S ^{[1
]}

KENNY, M ^{[1
]}

DULWORTH, J ^{[1
]}

EGGENSPILLER, A ^{[1
]}

机构：

[1] MARION MERRELL DOW INC, INDIANAPOLIS, IN 46268 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1992年 / 11卷 / 09期

关键词：

D O I：

10.1080/07328319208021352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New conformationaly constrained cycloalkanol derivatives of guanine have been prepared as potential anti-herpetic agents. None of these compounds was found to inhibit HSV or CMV replication in cell culture but some of them show some antagonism or synergism towards acyclovir protecting effect.

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页码：1595 / 1606

页数：12

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