ENCODING OF A HOMOLOG OF THE IFN-GAMMA RECEPTOR BY MYXOMA VIRUS

被引：295

作者：

UPTON, C ^{[1
]}

MOSSMAN, K ^{[1
]}

MCFADDEN, G ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT BIOCHEM, EDMONTON T6G 2H7, ALBERTA, CANADA

来源：

SCIENCE | 1992年 / 258卷 / 5086期

关键词：

D O I：

10.1126/science.1455233

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-gamma). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-gamma and inhibits the biological activity of extracellular IFN-gamma, one of the key regulatory cytokines in the host immune response against viral infections.

引用

页码：1369 / 1373

页数：5

共 32 条

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