COMPARATIVE-STUDY OF THE ACTION OF FLUNIXIN MEGLUMINE AND TOLFENAMIC ACID ON PROSTAGLANDIN-E2 SYNTHESIS IN BOVINE INFLAMMATORY EXUDATE

被引：18

作者：

ESPINASSE, J ^{[1
]}

THOUVENOT, JP ^{[1
]}

DALLE, S ^{[1
]}

GARCIA, J ^{[1
]}

SCHELCHER, F ^{[1
]}

SALAT, O ^{[1
]}

VALARCHER, JF ^{[1
]}

DAVAL, S ^{[1
]}

机构：

[1] HOP PURPAN,F-31059 TOULOUSE,FRANCE

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 1994年 / 17卷 / 04期

关键词：

D O I：

10.1111/j.1365-2885.1994.tb00244.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An acute non-immune inflammation model was used to compare the action of two non-steroidal anti-inflammatory drugs, flunixin meglumine and tolfenamic acid, on prostaglandin E2 (PGE2) Synthesis in bovine inflammatory exudate. The tissue cage model used involves subcutaneous implantation of polypropylene cages and subsequent stimulation by carrageenan injection of the granulation tissue which develops within the cage. Twelve calves were randomly assigned to three groups receiving placebo, flunixin meglumine and tolfenamic acid, respectively. Inflammatory exudate was sampled 30 min after carrageenan injection and at seven subsequent time points. PGE2 levels were determined by radioimmunoassay. At each time point post-carrageenan injection, flunixin meglumine inhibited PGE2 synthesis to a greater extent than tolfenamic acid. At 4, 8, 12 and 24 h these differences were statistically significant.

引用

页码：271 / 274

页数：4

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