THERMODYNAMIC CHARACTERIZATION OF THE 9-AMINOACRIDINE INTERCALATED INTO DNA

被引：7

作者：

BABA, Y

KUNIHIRO, A

KAGEMOTO, A

机构：

[1] Laboratory of Chemistry, Department of General Education, Osaka Institute of Technology, Asahi-ku, Osaka

来源：

THERMOCHIMICA ACTA | 1992年 / 202卷

关键词：

D O I：

10.1016/0040-6031(92)85168-U

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The interaction of DNA with 9-aminoacridine was studied by means of calorimetric and spectral measurements, and the thermodynamic quantities for 9-aminoacridine intercalated into DNA were determined. Changes in free energy DELTA-G, enthalpy DELTA-H, and entropy DELTA-S accompanying the intercalation process were estimated to be about -36 kJ mol-1, -22 kJ mol-1 and 47 J K-1 mol-1 respectively, suggesting that the interaction between DNA and 9-aminoacridine appears to form a stable complex from the viewpoint of free energy and that this complex formation is governed by both enthalpy and entropy.

引用

页码：241 / 248

页数：8