INDUCTION OF RAT HEPATIC AND INTESTINAL GLUTATHIONE S-TRANSFERASES BY DIETARY BUTYLATED HYDROXYANISOLE

被引：25

作者：

NIJHOFF, WA ^{[1
]}

PETERS, WHM ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN, HOSP ST RADBOUD, DIV GAST, POB 9101, 6500 HB NIJMEGEN, NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 03期

关键词：

D O I：

10.1016/0006-2952(92)90456-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To obtain insight into the protection mechanism of butylated hydroxyanisole (BHA), a widely used food preservative with anticarcinogenic properties, we investigated the effects of dietary BHA on rat hepatic and intestinal glutathione S-transferase (GST) enzyme activity, and GST isozyme levels. In the proximal small intestine and liver, BHA supplementation significantly increased GST enzyme activity as compared with controls (2.3- and 1.7-fold, respectively, P < 0.05). GST class-alpha and mu contents were significantly higher only in the small intestine (1.6-2. 1-fold and 1.3-1.5-fold, respectively, P < 0.05), whereas GST class-pi was significantly induced in liver (4.6-fold, P < 0.05).

引用

页码：596 / 600

页数：5

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