CD44 VARIANT ISOFORMS IN NON-HODGKINS-LYMPHOMA - A NEW INDEPENDENT PROGNOSTIC FACTOR

被引:225
作者
STAUDER, R [1 ]
EISTERER, W [1 ]
THALER, J [1 ]
GUNTHERT, U [1 ]
机构
[1] UNIV INNSBRUCK HOSP, DEPT INTERNAL MED, A-6020 INNSBRUCK, AUSTRIA
关键词
D O I
10.1182/blood.V85.10.2885.bloodjournal85102885
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Isoforms of the transmembrane glycoprotein CD44, generated by alternative RNA splicing, have been correlated to tumor dissemination, For evaluation of the potential role of CD44 variant isoforms in non-Hodgkin's lymphoma (NHL), the presence of CD44 isoforms was analyzed in a large panel of reactive and neoplastic lymphoid tissues by immunohistochemical staining, as well as detection of CD44 variant RNAs by the reverse transcriptase-polymerase chain reaction. Whereas the CD44 standard or hematopoietic isoform (CD44s), devoid of the variant regions, was expressed in all leukocyte subpopulations, the variant isoforms (CD44v) showed a highly restricted pattern of expression, mainly observed in epithelial layers of lymphoid tissues and subpopulations of leukocytes after stimulation. In addition to a strong expression of CD44s, variant isoforms containing CD44-6v in combination with other variant exons were observed predominantly in aggressive lymphoma and were associated with a shorter overall survival of patients (n = 138; P <.0001). Moreover, multivariate analysis indicated CD44-6v as a new independent prognostic parameter in high grade NHL in comparison with the risk groups defined by the International NHL Lymphoma Prognostic Factors Project (N Engl J Med 329:987, 1993). (C) 1995 by The American Society of Hematology.
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页码:2885 / 2899
页数:15
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