FUNCTIONAL-ANALYSIS OF THE PROMOTER OF THE SACCHAROMYCES-CEREVISIAE MULTIDRUG-RESISTANCE GENE YDR1, WHICH ENCODES A MEMBER OF THE ATP BINDING CASSETTE (ABC) SUPERFAMILY

被引：7

作者：

MIYAHARA, K

HIRATA, D

MIYAKAWA, T

机构：

[1] Department of Fermentation Technology, Hiroshima University

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 01期

关键词：

D O I：

10.1271/bbb.59.147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Guru, Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDB1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.

引用

页码：147 / 149

页数：3

共 9 条

[1]

BALZI E, 1994, J BIOL CHEM, V269, P2206

[2]

BISSINGER PH, 1994, J BIOL CHEM, V269, P4180

[3] BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER [J].