DIFFERENTIAL UTILIZATION OF CALCITONIN GENE REGULATORY DNA-SEQUENCES IN CULTURED LINES OF MEDULLARY-THYROID CARCINOMA AND SMALL-CELL LUNG-CARCINOMA

被引：27

作者：

DEBUSTROS, A

LEE, RY

COMPTON, D

TSONG, TY

BAYLIN, SB

NELKIN, BD

机构：

[1] Oncology Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231

[2] Dept. of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo

[3] Department of Biochemistry, University of Minnesota, College of Biological Sciences, St. Paul

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 04期

关键词：

D O I：

10.1128/MCB.10.4.1773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

引用

页码：1773 / 1778

页数：6

共 32 条

[1] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS
AMARA, SG
JONAS, V
ROSENFELD, MG
ONG, ES
EVANS, RM
[J]. NATURE, 1982, 298 (5871) : 240 - 244
[2] IDENTIFICATION OF THE PROMOTER SEQUENCES INVOLVED IN THE CELL SPECIFIC EXPRESSION OF THE RAT SOMATOSTATIN GENE
ANDRISANI, OM
HAYES, TE
ROOS, B
DIXON, JE
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (14) : 5715 - 5728
[3] CALCITONIN - PHYSIOLOGY AND PATHO-PHYSIOLOGY
AUSTIN, LA
HEATH, H
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (05) : 269 - 278
[4] Baylin S B, 1980, Endocr Rev, V1, P45
[5] SEPARATE CIS-REGULATORY ELEMENTS CONFER EXPRESSION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE IN DIFFERENT CELL-LINES
BENVENISTY, N
NECHUSHTAN, H
COHEN, H
RESHEF, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) : 1118 - 1122
[6] STRUCTURE AND METHYLATION OF THE HUMAN CALCITONIN ALPHA-CGRP GENE
BROAD, PM
SYMES, AJ
THAKKER, RV
CRAIG, RK
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (17) : 6999 - 7011
[7] CATE CC, 1986, CANCER RES, V46, P812
[8] COTE GJ, 1986, J BIOL CHEM, V261, P5524
[9] DEBUSTROS A, 1988, P NATL ACAD SCI USA, V85, P5693
[10] HORMONE PRODUCTION BY TUMORS - BIOLOGICAL AND CLINICAL ASPECTS
DEBUSTROS, A
BAYLIN, SB
[J]. CLINICS IN ENDOCRINOLOGY AND METABOLISM, 1985, 14 (01): : 221 - 256

← 1 2 3 4 →