DIFFERENTIAL UTILIZATION OF CALCITONIN GENE REGULATORY DNA-SEQUENCES IN CULTURED LINES OF MEDULLARY-THYROID CARCINOMA AND SMALL-CELL LUNG-CARCINOMA

被引：27

作者：

DEBUSTROS, A

LEE, RY

COMPTON, D

TSONG, TY

BAYLIN, SB

NELKIN, BD

机构：

[1] Oncology Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231

[2] Dept. of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo

[3] Department of Biochemistry, University of Minnesota, College of Biological Sciences, St. Paul

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 04期

关键词：

D O I：

10.1128/MCB.10.4.1773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

引用

页码：1773 / 1778

页数：6

共 32 条

[11] DEBUSTROS A, 1986, J BIOL CHEM, V261, P8036
[12] EXPRESSION OF THE HUMAN CALCITONIN CGRP GENE IN LUNG AND THYROID-CARCINOMA
EDBROOKE, MR
PARKER, D
MCVEY, JH
RILEY, JH
SORENSON, GD
PETTENGILL, OS
CRAIG, RK
[J]. EMBO JOURNAL, 1985, 4 (03) : 715 - 724
[13] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS
GORMAN, CM
MOFFAT, LF
HOWARD, BH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) : 1044 - 1051
[14] THE ROUS-SARCOMA VIRUS LONG TERMINAL REPEAT IS A STRONG PROMOTER WHEN INTRODUCED INTO A VARIETY OF EUKARYOTIC CELLS BY DNA-MEDIATED TRANSFECTION
GORMAN, CM
MERLINO, GT
WILLINGHAM, MC
PASTAN, I
HOWARD, BH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (22): : 6777 - 6781
[15] WIDESPREAD DISTRIBUTION OF BRONCHOPULMONARY ENDOCRINE-CELLS IMMUNOREACTIVE FOR CALCITONIN IN THE LUNG OF THE NORMAL ADULT-RAT
GOSNEY, JR
SISSONS, MCJ
[J]. THORAX, 1985, 40 (03) : 194 - 198
[16] DIVERSITY OF ALPHA-FETOPROTEIN GENE-EXPRESSION IN MICE IS GENERATED BY A COMBINATION OF SEPARATE ENHANCER ELEMENTS
HAMMER, RE
KRUMLAUF, R
CAMPER, SA
BRINSTER, RL
TILGHMAN, SM
[J]. SCIENCE, 1987, 235 (4784) : 53 - 58
[17] TRANSCRIPTION FACTOR AP-2 MEDIATES INDUCTION BY 2 DIFFERENT SIGNAL-TRANSDUCTION PATHWAYS - PROTEIN-KINASE-C AND CAMP
IMAGAWA, M
CHIU, R
KARIN, M
[J]. CELL, 1987, 51 (02) : 251 - 260
[18] ALTERNATIVE RNA PROCESSING EVENTS IN HUMAN CALCITONIN CALCITONIN GENE-RELATED PEPTIDE GENE-EXPRESSION
JONAS, V
LIN, CR
KAWASHIMA, E
SEMON, D
SWANSON, LW
MERMOD, JJ
EVANS, RM
ROSENFELD, MG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) : 1994 - 1998
[19] CALCITONIN GENE RELATED PEPTIDE IMMUNOREACTIVITY IN RAT LUNG - LIGHT AND ELECTRON-MICROSCOPIC STUDY
LAUWERYNS, JM
VANRANST, L
[J]. THORAX, 1987, 42 (03) : 183 - 189
[20] Leong S.S., 1981, ADV THYROID NEOPLASI, P95

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