COLLAGEN BASED BIOMATERIALS - AN IDEAL WAY OF INCREASING THEIR RESISTANCE TO INFECTION

被引:5
作者
GUNASEKARAN, S
CHVAPIL, M
机构
[1] Department of Surgery, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, United States
来源
BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS | 1988年 / 16卷 / 04期
关键词
Collagen; -; Gels;
D O I
10.3109/10731198809117568
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Resorcinol monoacetate (RMA) is a relatively water insoluble antibacterial agent which partially crosslinks collagen and has the potential to be an intrinsic antibiotic in collagenous bioprostheses. This study confirms the efficacy of RMA as a chemical that: (a) mildly crosslinks collagen at pH 3.5-4.5; (b) releases very slowly from the pretreated collagen sponge when washed in aqueous medium; (c) inhibits bacterial growth on the pretreated collagen sponges, at 2% (w/w) concentration, for at least 12 days; (d) remains biocompatible under treated conditions.
引用
收藏
页码:771 / 784
页数:14
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