EFFECT OF ASPIRIN AND VITAMIN-C AND VITAMIN-E ON SYNOVIAL RHEUMATOID ARTHRITIC AND OTHER CELLS

Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-aspirin, low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C. © 1979 Birkhäuser Verlag.