COOPERATIVE INTERACTIONS AT [KAINIC-H-3 ACID BINDING-SITES IN RAT AND HUMAN CEREBELLUM

被引：43

作者：

LONDON, ED

COYLE, JT

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT EXPTL THERAPEUT,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT BEHAV SCI,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 03期

关键词：

Cerebellum; Cooperativity; Dihydrokainic acid; Glutamic acid; Kainic acid; Receptor binding;

D O I：

10.1016/0014-2999(79)90186-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inhibition of the specific binding of [3H]kainic acid was studied in membranes isolated from rat and human cerebellum; the sequence of potencies in both species were: kainic acid > L-glutamic acid > dihydrokainic acid > D-glutamic acid. Whereas the Hill coefficient for unlabelled Kainate was 1.0, dihydrokainic acid and D- and L-glutamic acids exhibited negative cooperativity with Hill coefficients of near 0.5. This allosteric interaction of glutamic acid at the kainic acid recognition site suggests a biochemical correlate for the synergistic effects of these compounds in vivo. © 1979.

引用

页码：287 / 290

页数：4

共 10 条

[1] EFFECTS OF KAINIC ACID ON ION DISTRIBUTION AND ATP LEVELS OF STRIATAL SLICES INCUBATED INVITRO [J].