HYDRATION OF DNA BASES - ANALYSIS OF CRYSTALLOGRAPHIC DATA

被引:127
作者
SCHNEIDER, B [1 ]
COHEN, D [1 ]
BERMAN, HM [1 ]
机构
[1] RUTGERS STATE UNIV,DEPT COMP SCI,NEW BRUNSWICK,NJ 08903
关键词
D O I
10.1002/bip.360320703
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We present a systematic analysis of water structure around nucleic acid bases. We have examined 28 crystal structures of oligonucleotides, and have studied the patterns of water around the four bases, guanine, cytosine, adenine, and thymine. The geometries of water positions were calculated up to 4.00 angstrom from base atoms. We have found conformation-dependent differences in both the geometry and extent of hydration of the bases.
引用
收藏
页码:725 / 750
页数:26
相关论文
共 65 条