A CONVENIENT SYNTHESIS OF 6-HYDROXYHARMAN

被引：15

作者：

ROCCA, P ^{[1
]}

MARSAIS, F ^{[1
]}

GODARD, A ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INST NATL SCI APPL ROUEN,CNRS,IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,BP 08,F-76131 MONT ST AIGNAN,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 13期

关键词：

ALKALOID; BETA-CARBOLINE; CROSS-COUPLING; METALATION;

D O I：

10.1016/S0040-4039(00)73033-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-step synthesis of 6-hydroxyharman and 6-hydroxynorharman from benzene and pyridine blocks is described. The preparation of the two alpha-substituted beta-carbolines is based on a new synthetic methodology which involves reactions such as Directed Ortho Metalation and Heteroring Cross-Coupling.

引用

页码：2003 / 2004

页数：2

共 8 条

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