EVALUATION OF NEW BENZOPORPHYRIN DERIVATIVES WITH ENHANCED PDT EFFICACY

被引：36

作者：

PANDEY, RK ^{[1
]}

POTTER, WR ^{[1
]}

MEUNIER, I ^{[1
]}

SUMLIN, AB ^{[1
]}

SMITH, KM ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1995年 / 62卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1995.tb08727.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A first report on the biological evaluation of a series of isomerically pure benzoporphyrin derivatives (cis- and trans-isomers) as methyl esters is described. In preliminary in vivo studies, the n-hexyl ether analogues of both cis- and trans-isomers of benzoporphyrin derivatives were found to be more active than the industrially prepared benzoporphyrin derivative, a mixture of monocarboxylic acids (BPDMA, Quadralogic Technologies, Vancouver). Further studies with 4-de-vinyl-4-(1-hexyloxyethyl) benzoporphyrin derivative showed that, like BPDMA, it had reduced residual skin phototoxicity compared in mice with Photofrin(R). The uptake and clearance characteristics of BPDMA were also compared with the 4-(1-hexyloxyethyl)-derivative by in vivo reflection spectroscopy.

引用

页码：764 / 768

页数：5

共 12 条

[1] MURINE PHARMACOKINETICS AND ANTITUMOR EFFICACY OF THE PHOTODYNAMIC SENSITIZER 2-[1-HEXYLOXYETHYL]-2-DEVINYL PYROPHEOPHORBIDE-A [J].