HIGHER-CARBON SUGARS BY ENZYMATIC CHAIN EXTENSION OXIDATIVE GENERATION OF ALDOL PRECURSORS IN-SITU

被引：18

作者：

EYRISCH, O

KELLER, M

FESSNER, WD

机构：

[1] RHEIN WESTFAL TH AACHEN, DEPT ORGAN CHEM, D-52056 AACHEN, GERMANY

[2] UNIV FREIBURG, DEPT ORGAN CHEM & BIOCHEM, D-79104 FREIBURG, GERMANY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

关键词：

D O I：

10.1016/0040-4039(94)88414-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel multienzymatic approach for the preparation of complex carbohydrates by enzymic aldolization is presented in which both the aldol donor and acceptor components are generated in situ by air oxidation using microbial oxidases. The L-threo stereochemistry generated by the recombinant rhamnulose 1-phosphate aldolase has been established by X-ray structural analysis.

引用

收藏

页码：9013 / 9016

页数：4

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