INVESTIGATION INTO THE COMBINED EFFECTS OF ETHANOL AND CADMIUM ON RAT-LIVER AND KIDNEYS

被引：18

作者：

HOPF, G ^{[1
]}

BOCKER, R ^{[1
]}

BISCHOFF, J ^{[1
]}

WERNER, MG ^{[1
]}

ESTLER, CJ ^{[1
]}

机构：

[1] INST PHARMAKOL & TOXIKOL,LEHRSTUHL TOXIKOL & PHARMAKOL,UNIV STR 22,W-8520 ERLANGEN,GERMANY

来源：

ARCHIVES OF TOXICOLOGY | 1990年 / 64卷 / 06期

关键词：

Cadmium; Ethanol; Liver and kidney damage; Rats;

D O I：

10.1007/BF01977629

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

To examine the combined hepatotoxic and nephrotoxic effects of cadmium and ethanol, rats maintained on an ethanol containing liquid diet (5% w/w) were given cadmium either acutely (3×1 mg/kg IP) or sub-acutely (about 14 mg/kg/day PO for 6 weeks). Parameters tested were cadmium, zinc and copper contents of blood and various organs, metallothionein (MT) contents, polysome profile of liver and kidneys, serum SDH and GPT levels and creatinine clearance. Ethanol reduced the hepatic MT contents without altering the polysome profile and the zinc and copper contents. Cadmium on the other hand raised the MT contents in liver and kidneys. This effect of cadmium predominated in the combined treatment. Morphological examination and functional tests (SDH, GPT, creatinine clearance) indicate that cadmium does not enhance the toxic effects of ethanol, and vice versa. © 1990 Springer-Verlag.

引用

页码：470 / 473

页数：4

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