STEREOSELECTIVE EFFECTS IN THE SEPARATION OF ENANTIOMERS OF OMEPRAZOLE AND OTHER SUBSTITUTED BENZIMIDAZOLES ON DIFFERENT CHIRAL STATIONARY PHASES

被引：86

作者：

BALMER, K

PERSSON, BA

LAGERSTROM, PO

机构：

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 660卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)85121-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantioselective separation of omeprazole on different chiral stationary phases was investigated. The two enantiomers could be resolved on three different phases with immobilized protein, Chiral-AGP, Ultron ES-OVM and BSA-DSC, employing aqueous mobile phases with 2-propanol as organic modifier. On Chiralpak AD, an amylose-based chiral stationary phase, the enantiomers of omeprazole and three analogues could be separated using a non-polar hexane-ethanol mobile phase. For omeprazole the retention order wits reversed when 2-propanol was replaced with ethanol or methanol as the modifier of hexane in the mobile phase.

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页码：269 / 273

页数：5

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