REQUIREMENT OF MICROFILAMENTS IN SORTING OF ACTIN MESSENGER-RNA

被引：225

作者：

SUNDELL, CL ^{[1
]}

SINGER, RH ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT CELL BIOL,WORCESTER,MA 01655

来源：

SCIENCE | 1991年 / 253卷 / 5025期

关键词：

D O I：

10.1126/science.1891715

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the Three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.

引用

页码：1275 / 1277

页数：3

共 29 条

[1] LOCOMOTION OF FIBROBLASTS IN CULTURE .4. ELECTRON MICROSCOPY OF LEADING LAMELLA [J].

ABERCROM.M ;

HEAYSMAN, JE ;

PEGRUM, SM .

EXPERIMENTAL CELL RESEARCH, 1971, 67 (02) :359-&

[2] PROPULSION OF ORGANELLES ISOLATED FROM ACANTHAMOEBA ALONG ACTIN-FILAMENTS BY MYOSIN-I [J].

ADAMS, RJ ;

POLLARD, TD .

NATURE, 1986, 322 (6081) :754-756

[3] THE ROLE OF LOCALIZATION OF BICOID RNA IN ORGANIZING THE ANTERIOR PATTERN OF THE DROSOPHILA EMBRYO [J].

BERLETH, T ;

BURRI, M ;

THOMA, G ;

BOPP, D ;

RICHSTEIN, S ;

FRIGERIO, G ;

NOLL, M ;

NUSSLEINVOLHARD, C .

EMBO JOURNAL, 1988, 7 (06) :1749-1756

[4] EFFECT OF VIRAL-INFECTION ON HOST PROTEIN-SYNTHESIS AND MESSENGER-RNA ASSOCIATION WITH THE CYTOPLASMIC CYTOSKELETAL STRUCTURE [J].

BONNEAU, AM ;

DARVEAU, A ;

SONENBERG, N .

JOURNAL OF CELL BIOLOGY, 1985, 100 (04) :1209-1218

[5] TRANSLATIONAL CONTROL AND THE CYTOSKELETON IN PHYSARUM-POLYCEPHALUM [J].

BRODEUR, RD ;

JEFFERY, WR .

CELL MOTILITY AND THE CYTOSKELETON, 1987, 7 (02) :129-137

[6] MESSENGER-RNA IS TRANSLATED WHEN ASSOCIATED WITH THE CYTOSKELETAL FRAMEWORK IN NORMAL AND VSV-INFECTED HELA-CELLS [J].

CERVERA, M ;

DREYFUSS, G ;

PENMAN, S .

CELL, 1981, 23 (01) :113-120

[7] ASYMMETRIC DISTRIBUTION OF ACTIN MESSENGER-RNA AND CYTOSKELETAL PATTERN GENERATION IN POLARIZED EPITHELIAL-CELLS [J].

CHENG, H ;

BJERKNES, M .

JOURNAL OF MOLECULAR BIOLOGY, 1989, 210 (03) :541-549

[8] DETECTION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT MESSENGER-RNA BY INSITU HYBRIDIZATION AT NEUROMUSCULAR-JUNCTIONS OF 15-DAY-OLD CHICK STRIATED MUSCLES [J].

FONTAINE, B ;

SASSOON, D ;

BUCKINGHAM, M ;

CHANGEUX, JP .

EMBO JOURNAL, 1988, 7 (03) :603-609

[9] SELECTIVE LOCALIZATION OF MESSENGER-RNA FOR CYTOSKELETAL PROTEIN MAP2 IN DENDRITES [J].

GARNER, CC ;

TUCKER, RP ;

MATUS, A .

NATURE, 1988, 336 (6200) :674-677

[10] BETA ACTIN AND ITS MESSENGER-RNA ARE LOCALIZED AT THE PLASMA-MEMBRANE AND THE REGIONS OF MOVING CYTOPLASM DURING THE CELLULAR-RESPONSE TO INJURY [J].

HOOCK, TC ;

NEWCOMB, PM ;

HERMAN, IM .

JOURNAL OF CELL BIOLOGY, 1991, 112 (04) :653-664

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