REQUIREMENT OF MICROFILAMENTS IN SORTING OF ACTIN MESSENGER-RNA

被引：225

作者：

SUNDELL, CL ^{[1
]}

SINGER, RH ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT CELL BIOL,WORCESTER,MA 01655

来源：

SCIENCE | 1991年 / 253卷 / 5025期

关键词：

D O I：

10.1126/science.1891715

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the Three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.

引用

页码：1275 / 1277

页数：3

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