PLE CATALYZED HYDROLYZES OF ALPHA-SUBSTITUTED ALPHA-HYDROXY ESTERS - THE INFLUENCE OF THE SUBSTITUENTS

被引：25

作者：

MOORLAG, H ^{[1
]}

KELLOGG, RM ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT ORGAN CHEM,NIJENBORGH 16,9747 AG GRONINGEN,NETHERLANDS

来源：

TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)86125-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enzymatic hydrolyses of a variety of alpha-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various alpha-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for alpha-substituted lactic esters. We observed that the enantioselectivity of PLE depends strongly on the length and nature of the substituent at the alpha-position. Some consequences for an active site model of PLE are discussed.

引用

页码：705 / 720

页数：16

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