REACTIVE OXYGEN SPECIES AND IRON - A DANGEROUS PARTNERSHIP IN INFLAMMATION

被引:113
作者
MORRIS, CJ
EARL, JR
TRENAM, CW
BLAKE, DR
机构
[1] The Inflammation Research Group, The London Hospital Medical College, London, E1 2AD
关键词
INFLAMMATION; REACTIVE OXYGEN SPECIES; IRON; REPERFUSION INJURY; NITRIC OXIDE; TRANSCRIPTION FACTORS;
D O I
10.1016/1357-2725(94)00084-O
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cells of nearly all forms of life require well-defined amounts of iron for survival, replication and expression of differentiated processes. It has a central role in erythropoiesis but is also involved in many other intracellular processes in the tissues of the body. It is the fourth most abundant element in the Earth's crust and the most abundant transition metal in living organisms for which its characteristic chemistry endows it with a series of properties enabling it to fulfil certain biological reactions especially those involving redox mechanisms. It is involved in the transport of oxygen, in electron transfer, in the synthesis of DNA, in oxidations by oxygen (O-2) and hydrogen peroxide (H2O2) and in many other processes maintaining normal structure and function of virtually all mammalian cells. Because an iron atom can exist in two valency states, ferrous and ferric, iron became the primordial partner of oxygen in evolution. However, as de Sousa et al. (1989) state, such long standing partnerships have to use protective devices to ensure that the toxicity of neither partner is expressed in the presence of the other. Here, we discuss this dangerous partnership and its relevance to inflammation. The main themes of this review are the known roles of iron in the generation of reactive oxygen intermediates and new developments, including iron and transcription and the reaction of iron with nitric oxide. We also consider the widening recognition of the importance of oxygen metabolites in hypoxia-reperfusion injury and disease of the skin and joint.
引用
收藏
页码:109 / 122
页数:14
相关论文
共 98 条
[1]   OVERLOAD OF IRON IN THE SKIN OF PATIENTS WITH VARICOSE ULCERS - POSSIBLE CONTRIBUTING ROLE OF IRON ACCUMULATION IN PROGRESSION OF THE DISEASE [J].
ACKERMAN, Z ;
SEIDENBAUM, M ;
LOEWENTHAL, E ;
RUBINOW, A .
ARCHIVES OF DERMATOLOGY, 1988, 124 (09) :1376-1378
[2]  
AMSTAD PA, 1992, CANCER RES, V52, P3952
[3]   SUPEROXIDE-DEPENDENT AND ASCORBATE-DEPENDENT FORMATION OF HYDROXYL RADICALS FROM HYDROGEN-PEROXIDE IN THE PRESENCE OF IRON - ARE LACTOFERRIN AND TRANSFERRIN PROMOTERS OF HYDROXYL-RADICAL GENERATION [J].
ARUOMA, OI ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1987, 241 (01) :273-278
[4]  
BAEUERLE PA, 1991, HORMONAL CONTROL REG, P423
[5]   ENHANCED PRODUCTION OF HYDROXYL RADICALS BY THE XANTHINE-XANTHINE OXIDASE REACTION IN THE PRESENCE OF LACTOFERRIN [J].
BANNISTER, JV ;
BANNISTER, WH ;
HILL, HAO ;
THORNALLEY, PJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 715 (01) :116-120
[6]   OXIDATIVE DNA-DAMAGE AND CELLULAR-SENSITIVITY TO OXIDATIVE STRESS IN HUMAN AUTOIMMUNE-DISEASES [J].
BASHIR, S ;
HARRIS, G ;
DENMAN, MA ;
BLAKE, DR ;
WINYARD, PG .
ANNALS OF THE RHEUMATIC DISEASES, 1993, 52 (09) :659-666
[7]   LOCALIZED HEMOSIDEROSIS AS A SEQUELA OF ACNE [J].
BASLER, RSW ;
KOHNEN, PW .
ARCHIVES OF DERMATOLOGY, 1978, 114 (11) :1695-1697
[8]   APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].
BECKMAN, JS ;
BECKMAN, TW ;
CHEN, J ;
MARSHALL, PA ;
FREEMAN, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624
[9]   PATHOLOGICAL IMPLICATIONS OF NITRIC-OXIDE, SUPEROXIDE AND PEROXYNITRITE FORMATION [J].
BECKMAN, JS ;
CROW, JP .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (02) :330-334
[10]  
BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229, DOI DOI 10.1016/S0076-6879(94)33026-3