IDENTIFICATION OF CATALYTIC PATHWAYS IN THE PEROXIDATIC REACTIONS OF THE HEME OCTAPEPTIDE MICROPEROXIDASE-8

被引：19

作者：

CUNNINGHAM, ID

SNARE, GR

机构：

[1] Department of Chemistry, University of Surrey

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1992年 / 11期

关键词：

D O I：

10.1039/p29920002019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of microperoxidase-8 (MP-8) with H2O2 leads to the formation of an oxidized intermediate whose subsequent reduction by 2,4-dimethoxyphenol occurs in two stages and results in regeneration of MP-8. Analysis of the kinetics of these reactions in comparison with those of the normal peroxidatic reaction shows that at least four oxidized forms of MP-8 are capable of oxidizing the phenol. Possible structures and modes of action for these intermediates are discussed.

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页码：2019 / 2023

页数：5

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