HISTOPATHOLOGICAL CORRELATIONS OF NUCLEAR-MAGNETIC-RESONANCE IMAGING PARAMETERS IN EXPERIMENTAL CEREBRAL-ISCHEMIA

被引：79

作者：

HELPERN, JA

DERESKI, MO

KNIGHT, RA

ORDIDGE, RJ

CHOPP, M

QING, ZX

机构：

[1] NIH Center for Cerebrovascular Disease Research, Department of Neurology

[2] Department of Radiation Oncology, Henry Ford Health Sciences Center, Detroit

[3] Department of Physics, Oakland University, Rochester

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 02期

关键词：

NMR; MRI; DIFFUSION; HISTOPATHOLOGY; CEREBRAL ISCHEMIA; STROKE;

D O I：

10.1016/0730-725X(93)90028-C

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Changes in the nuclear magnetic resonance (NMR) parameters of spin-lattice relaxation (T1), spin-spin relaxation (T2), proton density (rho), and water diffusion (D(NMR)) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle cerebral artery occlusion (MCA-O). Histological response ranged from severe irreversible damage (necrosis and cavitation) to relatively mild and apparently reversible damage. D(NMR) was the only NMR parameter which demonstrated a statistically significant change in all three regions of brain studied. Additionally, rho was significantly increased only in the region of brain studied which eventually progressed to necrosis and cavitation. Finally, data are presented which indicate that changes in T2, D(NMR), and rho can occur independently of one another.

引用

页码：241 / 246

页数：6

共 25 条

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