NITRIC-OXIDE SYNTHASE MESSENGER-RNA EXPRESSION IN HUMAN SUBTHALAMIC NUCLEUS, STRIATUM AND GLOBUS-PALLIDUS - IMPLICATIONS FOR BASAL GANGLIA FUNCTION

被引：28

作者：

NISBET, AP

FOSTER, OJF

KINGSBURY, A

LEES, AJ

MARSDEN, CD

机构：

[1] MIDDLESEX HOSP, DEPT NEUROL, LONDON W1N 8AA, ENGLAND

[2] UCL NATL HOSP NEUROL & NEUROSURG, LONDON WC1N 3BG, ENGLAND

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 22卷 / 1-4期

关键词：

NITRIC OXIDE SYNTHASE; SUBTHALAMIC NUCLEUS; STRIATUM; GLOBUS PALLIDUS; MESSENGER-RNA; IN SITU HYBRIDIZATION; HUMAN BRAIN; COEXPRESSION;

D O I：

10.1016/0169-328X(94)90062-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of NOS mRNA within human basal ganglia was investigated using in situ hybridisation histochemistry (ISHH). Greater than 95% of subthalamic nucleus neurons were NOS mRNA-positive, between 1.5% and 2% of striatal neurons were positive and scattered NOS mRNA-positive neurons were detected in the medial, but not lateral globus pallidus. Levels of NOS mRNA expression per neuron were considerably higher in the striatum than in the pallidum or subthalamus. These findings have implications for basal ganglia function and disease states.

引用

收藏

页码：329 / 332

页数：4

相关论文

共 19 条

[1] LESION OF THE SUBTHALAMIC NUCLEUS FOR THE ALLEVIATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED PARKINSONISM IN THE PRIMATE [J].

AZIZ, TZ ;

PEGGS, D ;

SAMBROOK, MA ;

CROSSMAN, AR .

MOVEMENT DISORDERS, 1991, 6 (04) :288-292

[2] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BOHME, GA ;

BON, C ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 199 (03) :379-381

[3]

BOLAM JP, 1984, CIBA F SYMP, V107, P30

[4] NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE [J].

BREDT, DS ;

GLATT, CE ;

HWANG, PM ;

FOTUHI, M ;

DAWSON, TM ;

SNYDER, SH .

NEURON, 1991, 7 (04) :615-624

[5] A NOVEL NEURONAL MESSENGER MOLECULE IN BRAIN - THE FREE-RADICAL, NITRIC-OXIDE [J].

DAWSON, TM ;

DAWSON, VL ;

SNYDER, SH .

ANNALS OF NEUROLOGY, 1992, 32 (03) :297-311

[6] NITRIC-OXIDE SYNTHASE AND NEURONAL NADPH DIAPHORASE ARE IDENTICAL IN BRAIN AND PERIPHERAL-TISSUES [J].

DAWSON, TM ;

BREDT, DS ;

FOTUHI, M ;

HWANG, PM ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7797-7801

[7] AGING AND PARKINSONS-DISEASE - SUBSTANTIA-NIGRA REGIONAL SELECTIVITY [J].

FEARNLEY, JM ;

LEES, AJ .

BRAIN, 1991, 114 :2283-2301

[8] NEUROPEPTIDE-Y AND TYROSINE-HYDROXYLASE MESSENGER-RNA LEVELS IN THE LOCUS-COERULEUS SHOW SIMILAR INCREASES AFTER RESERPINE TREATMENT [J].

FOSTER, OJF ;

BISWAS, S ;

LIGHTMAN, SL .

NEUROPEPTIDES, 1991, 18 (03) :137-141

[9] RELATIVE SPARING OF NITRIC-OXIDE SYNTHASE CONTAINING NEURONS IN THE HIPPOCAMPAL-FORMATION IN ALZHEIMERS-DISEASE [J].

HYMAN, BT ;

MARZLOFF, K ;

WENNIGER, JJ ;

DAWSON, TM ;

BREDT, DS ;

SNYDER, SH .

ANNALS OF NEUROLOGY, 1992, 32 (06) :818-820

[10] CLONED AND EXPRESSED MACROPHAGE NITRIC-OXIDE SYNTHASE CONTRASTS WITH THE BRAIN ENZYME [J].

LOWENSTEIN, CJ ;

GLATT, CS ;

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :6711-6715