BACLOFEN FACILITATES THE DEVELOPMENT OF LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS

被引：37

作者：

MOTT, DD

LEWIS, DV

FERRARI, CM

WILSON, WA

SWARTZWELDER, HS

机构：

[1] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT PEDIAT NEUROL,DURHAM,NC 27710

[3] DUKE UNIV,MED CTR,DEPT MED NEUROL,DURHAM,NC 27710

[4] DUKE UNIV,MED CTR,DEPT PSYCHOL,DURHAM,NC 27710

[5] VET ADM MED CTR,NEUROL RES LAB,DURHAM,NC 27705

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期

关键词：

Baclofen; Dentate gyrus; Disinhibition; GABA[!sub]B[!/sub] receptor; Hippocampal formation; Long-term potentiation;

D O I：

10.1016/0304-3940(90)90307-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked response than did similar stimulation in control medium. In addition, baclofen enabled stimulus trains, ordinarily subthreshold for LTP induction, to produce LTP. These results demonstrate that GABAB receptor activation by baclofen makes repetitive stimulation more effective at producing LTP. © 1990.

引用

页码：222 / 226

页数：5

共 16 条

[11] EFFECTS OF (-)BACLOFEN ON INHIBITORY NEURONS IN THE GUINEA-PIG HIPPOCAMPAL SLICE [J].