HISTORICAL ASPECTS OF GLUTATHIONE AND CANCER-CHEMOTHERAPY

被引：46

作者：

MISTRY, P

HARRAP, KR

机构：

[1] Drug Development Section, The Institute of Cancer Research, tton, Surrey SM2 5NG, Cotswold Road

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0163-7258(91)90026-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This presentation sets in historical context the impact of glutathione and its metabolism upon the efficacy of several anticancer drugs. The basic biochemistry of the tripeptide is reviewed briefly highlighting its role in oxido-reduction and in the gamma-glutamyl cycle. The ability of selective modulators of glutathione metabolism, such as buthionine sulfoximine, as adjuncts to chemotherapy is also discussed.

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页码：125 / 132

页数：8

相关论文

共 100 条

[1] ENHANCED POTENTIATION OF CISPLATIN CYTO-TOXICITY IN HUMAN OVARIAN-CARCINOMA CELLS BY PROLONGED GLUTATHIONE DEPLETION [J].

ANDREWS, PA ;

SCHIEFER, MA ;

MURPHY, MP ;

HOWELL, SB .

CHEMICO-BIOLOGICAL INTERACTIONS, 1988, 65 (01) :51-58

[2]

ANDREWS PA, 1985, CANCER RES, V45, P6250

[3]

ANDREWS PA, 1986, MOL PHARMACOL, V30, P643

[4]

ANDREWS PA, 1987, CANCER CHEMOTH PHARM, V19, P149

[5] INTERACTIONS AMONG IRON(II) BLEOMYCIN, LEWIS-BASES, AND DNA [J].

ANTHOLINE, WE ;

PETERING, DH ;

SARYAN, LA ;

BROWN, CE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7517-7520

[6]

ARRICK BA, 1984, CANCER RES, V44, P4224

[7] PROTECTIVE ROLE OF THE GLUTATHIONE REDOX CYCLE AGAINST ADRIAMYCIN-MEDIATED TOXICITY IN ISOLATED HEPATOCYTES [J].

BABSON, JR ;

ABELL, NS ;

REED, DJ .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (16) :2299-2304

[8] INACTIVATION OF GLUTATHIONE REDUCTASE BY 2-CHLOROETHYL NITROSOUREA-DERIVED ISOCYANATES [J].

BABSON, JR ;

REED, DJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (02) :754-762

[9] NADPH CYTOCHROME-P-450 REDUCTASE ACTIVATION OF QUINONE ANTI-CANCER AGENTS TO FREE-RADICALS [J].

BACHUR, NR ;

GORDON, SL ;

GEE, MV ;

KON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (02) :954-957

[10] RESISTANCE AGAINST CIS-DICHLORODIAMMINEPLATINUM IN CULTURED-CELLS WITH A HIGH CONTENT OF METALLOTHIONEIN [J].

BAKKA, A ;

ENDRESEN, L ;

JOHNSEN, ABS ;

EDMINSON, PD ;

RUGSTAD, HE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 61 (02) :215-226

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