HISTORICAL ASPECTS OF GLUTATHIONE AND CANCER-CHEMOTHERAPY

被引：46

作者：

MISTRY, P

HARRAP, KR

机构：

[1] Drug Development Section, The Institute of Cancer Research, tton, Surrey SM2 5NG, Cotswold Road

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0163-7258(91)90026-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This presentation sets in historical context the impact of glutathione and its metabolism upon the efficacy of several anticancer drugs. The basic biochemistry of the tripeptide is reviewed briefly highlighting its role in oxido-reduction and in the gamma-glutamyl cycle. The ability of selective modulators of glutathione metabolism, such as buthionine sulfoximine, as adjuncts to chemotherapy is also discussed.

引用

页码：125 / 132

页数：8

共 100 条

[91]

SUZUKAKE K, 1982, BIOCHEM PHARMACOL, V31, P121

[92] ON MECHANISM OF ACTION OF BLEOMYCIN - SCISSION OF DNA STRANDS IN VITRO AND IN VIVO [J].