THE MOLECULAR-BIOLOGY OF DESMOSOMES AND HEMIDESMOSOMES - WHATS IN A NAME

被引：68

作者：

LEGAN, PK ^{[1
]}

COLLINS, JE ^{[1
]}

GARROD, DR ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON, SCH BIOMED SCI, DEPT BIOL, SOUTHAMPTON SO9 3TU, HANTS, ENGLAND

来源：

BIOESSAYS | 1992年 / 14卷 / 06期

关键词：

D O I：

10.1002/bies.950140608

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function.

引用

页码：385 / 393

页数：9

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