EVALUATION OF DRUG CANDIDATES IN A BATTERY OF SHORT-TERM GENETIC TOXICOLOGY ASSAYS - OVERVIEW

被引：4

作者：

AARON, CS

机构：

来源：

MUTATION RESEARCH | 1989年 / 223卷 / 02期

关键词：

D O I：

10.1016/0165-1218(89)90038-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：105 / 109

页数：5

共 8 条

[1] COMPARATIVE MUTAGENICITY TESTING OF A DRUG CANDIDATE, U-48753E - MECHANISM OF INDUCTION OF GENE-MUTATIONS IN MAMMALIAN-CELLS AND QUANTITATION OF POTENTIAL HAZARD [J].

AARON, CS ;

STANKOWSKI, LF ;

HARBACH, PR ;

VALENCIA, R ;

MAYO, JK ;

MIRSALIS, J ;

MAZUREK, JH ;

STEINMETZ, KL ;

WISER, SK ;

ZIMMER, DM ;

TRZOS, RJ .

MUTATION RESEARCH, 1989, 223 (02) :111-120

[2] COMPARISON OF THE AS52/XPRT AND THE CHO/HPRT ASSAYS - EVALUATION OF 6 DRUG CANDIDATES [J].

AARON, CS ;

STANKOWSKI, LF .

MUTATION RESEARCH, 1989, 223 (02) :121-128

[3] THE INVITRO UNSCHEDULED DNA-SYNTHESIS (UDS) ASSAY IN RAT PRIMARY HEPATOCYTES - EVALUATION OF 2-FUROIC ACID AND 7 DRUG CANDIDATES [J].

AARON, CS ;

HARBACH, PR ;

WISER, SK ;

GRZEGORCZYK, CR ;

SMITH, AL .

MUTATION RESEARCH, 1989, 223 (02) :163-169

[4] THE CHO/HPRT ASSAY - EVALUATION OF 19 DRUG CANDIDATES [J].

AARON, CS ;

STANKOWSKI, LF ;

ZIMMER, DM .

MUTATION RESEARCH, 1989, 223 (02) :153-161

[5] THE MOUSE BONE-MARROW MICRONUCLEUS TEST - EVALUATION OF 21 DRUG CANDIDATES [J].

AARON, CS ;

SORG, R ;

ZIMMER, D .

MUTATION RESEARCH, 1989, 223 (02) :129-140

[6] THE SALMONELLA MUTAGENICITY TEST - EVALUATION OF 29 DRUG CANDIDATES [J].

AARON, CS ;

MAZUREK, J ;

ZIMMER, DM ;

SWENSON, DH .

MUTATION RESEARCH, 1989, 223 (02) :171-182

[7] THE INVITRO UNSCHEDULED DNA-SYNTHESIS (UDS) ASSAY IN RAT PRIMARY HEPATOCYTES - EVALUATION OF 24 DRUG CANDIDATES [J].

AARON, CS ;

HARBACH, PR ;

STEINMETZ, KL ;

BAKKE, JP ;

MIRSALIS, JC .

MUTATION RESEARCH, 1989, 223 (02) :141-151

[8] PREDICTION OF CHEMICAL CARCINOGENICITY IN RODENTS FROM INVITRO GENETIC TOXICITY ASSAYS [J].

TENNANT, RW ;

MARGOLIN, BH ;

SHELBY, MD ;

ZEIGER, E ;

HASEMAN, JK ;

SPALDING, J ;

CASPARY, W ;

RESNICK, M ;

STASIEWICZ, S ;

ANDERSON, B ;

MINOR, R .

SCIENCE, 1987, 236 (4804) :933-941

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