DISCONTINUOUS ABSORPTION PROCESSES IN PHARMACOKINETIC MODELS

被引:28
作者
SUVERKRUP, R
机构
[1] Pharmazeutisches Institut, Universitát Bonn, Bonn, 5300, An der Immenburg
关键词
Bioavailability—pharmacokinetic models; limited absorption time; fraction of dose absorbed; Drug absorption—pharmacokinetic models; Models; pharmacokinetic—bioavailability;
D O I
10.1002/jps.2600681115
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The limited contact time of absorbable drug with absorbing surfaces is, in some cases, a significant factor determining the fraction of the dose absorbed. A simple modification of customary linear compartmental models is presented to account for this situation, and a general input function in the Laplace domain for truncated first‐order absorption is derived. An extension to series of truncated absorption processes is discussed. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:1395 / 1400
页数:6
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