DISCONTINUOUS ABSORPTION PROCESSES IN PHARMACOKINETIC MODELS

被引：28

作者：

SUVERKRUP, R

机构：

[1] Pharmazeutisches Institut, Universitát Bonn, Bonn, 5300, An der Immenburg

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 11期

关键词：

Bioavailability—pharmacokinetic models; limited absorption time; fraction of dose absorbed; Drug absorption—pharmacokinetic models; Models; pharmacokinetic—bioavailability;

D O I：

10.1002/jps.2600681115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The limited contact time of absorbable drug with absorbing surfaces is, in some cases, a significant factor determining the fraction of the dose absorbed. A simple modification of customary linear compartmental models is presented to account for this situation, and a general input function in the Laplace domain for truncated first‐order absorption is derived. An extension to series of truncated absorption processes is discussed. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1395 / 1400

页数：6

共 17 条

[11]

KUBLER W, 1965, GASTROENTEROLOGIA S, V104, P231

[12] NEW METHOD FOR CALCULATING INTRINSIC ABSORPTION RATE OF DRUGS [J].