Sarcotrine G, a New Derivative Isolated from a Marine Sponge Sarcotragus Species

被引：2

作者：

Hwang, Buyng Su ^{[1
]}

Park, Su Young ^{[1
]}

Park, Myung Gil ^{[2
]}

Rho, Jung-Rae ^{[1
]}

机构：

[1] Kunsan Natl Univ, Dept Oceanog, Kunsan 573701, South Korea

[2] Chonnam Natl Univ, Dept Oceanog, Gwangju 500757, South Korea

来源：

JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY | 2008年 / 12卷 / 01期

关键词：

I D and 2D NMR; Sarcotrine G; Sponge Sarcotragus sp; AMPK activation;

D O I：

10.6564/JKMRS.2008.12.1.033

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Four sesterterpenoids were isolated from AMPK activity-guided fraction of marine sponge Sarcotragus species. Their planar structures were determined from combination of extensive ID and 2D NMR experiments and MS data, and the configuration at the chiral centers were assigned by comparison with the ' H and 13C chemical shifts of the known compounds. Among four compounds, compound 2 was found to be a new sarcotrine derivative. Though not strong, compounds 1-4 moderately showed AMPK activation effect on L6 myoblast cell through Western Blot analysis.

引用

页码：33 / 39

页数：7

共 10 条

[1] Marine natural products [J].

Blunt, John W. ;

Copp, Brent R. ;

Hu, Wan-Ping ;

Munro, Murray H. G. ;

Northcote, Peter T. ;

Prinsep, Michele R. .

NATURAL PRODUCT REPORTS, 2008, 25 (01) :35-94

[2] THE STRUCTURE OF ERYLOSIDE A, A NEW ANTITUMOR AND ANTIFUNGAL 4-METHYLATED STEROIDAL GLYCOSIDE FROM THE SPONGE ERYLUS-LENDENFELDI [J].

CARMELY, S ;

ROLL, M ;

LOYA, Y ;

KASHMAN, Y .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (01) :167-170

[3] Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome [J].

Cool, Barbara ;

Zinker, Bradley ;

Chiou, William ;

Kifle, Lemma ;

Cao, Ning ;

Perham, Matthew ;

Dickinson, Robert ;

Adler, Andrew ;

Gagne, Gerard ;

Iyengar, Rajesh ;

Zhao, Gang ;

Marsh, Kennan ;

Kym, Philip ;

Jung, Paul ;

Camp, Heidi S. ;

Frevert, Ernst .

CELL METABOLISM, 2006, 3 (06) :403-416

[4] BIOACTIVE MARINE METABOLITES .30. ASTROGORGIADIOL AND ASTROGORGIN, INHIBITORS OF CELL-DIVISION IN FERTILIZED STARFISH EGGS, FROM A GORGONIAN ASTROGORGIA SP [J].

FUSETANI, N ;

NAGATA, H ;

HIROTA, H ;

TSUYUKI, T .

TETRAHEDRON LETTERS, 1989, 30 (50) :7079-7082

[5] AMP-activated protein kinase - development of the energy sensor concept [J].

Hardie, D. Grahame ;

Hawley, Simon A. ;

Scott, Johnw. .

JOURNAL OF PHYSIOLOGY-LONDON, 2006, 574 (01) :7-15

[6]

Kerr R. G., 1999, NAT PROD REP, V8, P441

[7] New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus [J].

Liu, YH ;

Mansoor, TA ;

Hong, JK ;

Lee, CO ;

Sim, CJ ;

Im, KS ;

Kim, ND ;

Jung, JH .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (11) :1451-1456

[8] Cytotoxic pyrrolo- and furanoterpenoids from the sponge Sarcotragus species [J].

Liu, YH ;

Hong, JK ;

Lee, CO ;

Im, KS ;

Kim, ND ;

Choi, JS ;

Jung, JH .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (09) :1307-1314

[9]

Rho J-R, 2003, J KOR MAGN RESON, V7, P55

[10] Sarcotragins A and B, new sesterterpenoid alkaloids from the sponge Sarcotragus sp. [J].

Shin, J ;

Rho, JR ;

See, Y ;

Lee, HS ;

Cho, KW ;

Sim, CJ .

TETRAHEDRON LETTERS, 2001, 42 (16) :3005-3007

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