NEUROTRANSMITTERS AND 2ND MESSENGERS IN AGING AND ALZHEIMERS-DISEASE

被引：22

作者：

FRANCIS, PT

WEBSTER, MT

CHESSELL, IP

HOLMES, C

STRATMANN, GC

PROCTER, AW

CROSS, AJ

GREEN, AR

BOWEN, DM

机构：

[1] INST NEUROL,MIRIAM MARKS DEPT NEUROCHEM,LONDON WC1N 1PJ,ENGLAND

[2] ASTRA NEUROSCI RES UNIT,LONDON WC1N 1PJ,ENGLAND

来源：

ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION | 1993年 / 695卷

关键词：

D O I：

10.1111/j.1749-6632.1993.tb23021.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A substantial loss of cortical cholinergic nerve endings, along with a much more circumscribed cortical degeneration of pyramidal neurons, almost certainly causes glutamatergic hypoactivity in live Alzheimer's patients. These selective pathologies are discussed in terms of therapy. An additional effect of some proposed treatments is emerging as there is evidence that processing pathways for beta-amyloid precursor proteins in cortical pyramidal neurons, a target cell for acetylcholine, are affected by neuronal activity.

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页码：19 / 26

页数：8

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