CYTOKINE PRODUCTION AND REQUIREMENTS DURING T-CELL DEVELOPMENT

被引：95

作者：

ZLOTNIK, A

MOORE, TA

机构：

[1] Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80005-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cellularity, making IL-7 the first cytokine shown to be necessary for normal intrathymic T-cell development.

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页码：206 / 213

页数：8

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