CONSTITUTIVE EXPRESSION OF PORE-FORMING PROTEIN IN PERIPHERAL-BLOOD GAMMA-DELTA-T-CELLS - IMPLICATION FOR THEIR CYTOTOXIC ROLE INVIVO

被引:108
作者
NAKATA, M
SMYTH, MJ
NORIHISA, Y
KAWASAKI, A
SHINKAI, Y
OKUMURA, K
YAGITA, H
机构
[1] JUNTENDO UNIV, SCH MED, DEPT IMMUNOL, 2-1-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
[2] NCI, FREDERICK CANC RES & DEV CTR, EXPTL IMMUNOL LAB, FREDERICK, MD 21701 USA
关键词
D O I
10.1084/jem.172.6.1877
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cytotoxic activity and pore-forming protein (PFP) expression of human peripheral blood (PB) γ/δ T cells were examined. Fresh γ/δ T cells isolated from PB lymphocytes by fluorescenceactivated cell sorting exhibited a substantial natural killer-like cytotoxic activity against K562 target cells and had a high cytotoxic potential triggered by anti-CD3 monoclonal antibody (mAb) against P815 target cells bearing Fc γR. Immunocytochemical staining with an anti-PFP mAb revealed that virtually all PB γ/δ T cells are granular lymphocytes with abundant PFP in their cytoplasmic granules. Constitutive expression of PFP in PB 'y/6 T cells was also demonstrated by Northern blot analysis. These observations support the proposed role ofγ/δ T cells in cytolysic immune surveillance in vivo. © 1990, Rockefeller University Press., All rights reserved.
引用
收藏
页码:1877 / 1880
页数:4
相关论文
共 16 条
  • [11] IMMUNOLOGY - ANTIGENS FOR GAMMA-DELTA T-CELLS
    RAULET, DH
    [J]. NATURE, 1989, 339 (6223) : 342 - 343
  • [12] MOLECULAR-CLONING AND CHROMOSOMAL ASSIGNMENT OF A HUMAN PERFORIN (PFP) GENE
    SHINKAI, Y
    YOSHIDA, MC
    MAEDA, K
    KOBATA, T
    MARUYAMA, K
    YODOI, J
    YAGITA, H
    OKUMURA, K
    [J]. IMMUNOGENETICS, 1989, 30 (06) : 452 - 457
  • [13] INTERLEUKIN-2 INDUCTION OF PORE-FORMING PROTEIN GENE-EXPRESSION IN HUMAN PERIPHERAL-BLOOD CD8+ T-CELLS
    SMYTH, MJ
    ORTALDO, JR
    SHINKAI, Y
    YAGITA, H
    NAKATA, M
    OKUMURA, K
    YOUNG, HA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) : 1269 - 1281
  • [14] SMYTH MJ, 1990, J IMMUNOL, V145, P1159
  • [15] SUBPOPULATIONS OF HUMAN PERIPHERAL-T-GAMMA-DELTA-LYMPHOCYTES
    TRIEBEL, F
    HERCEND, T
    [J]. IMMUNOLOGY TODAY, 1989, 10 (06): : 186 - 188
  • [16] PERFORIN-MEDIATED TARGET-CELL LYSIS BY CYTOLYTIC LYMPHOCYTE-T
    TSCHOPP, J
    NABHOLZ, M
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 : 279 - 302