SYNTHESIS OF QUINOLINES VIA ORTHO-LITHIATED N-ACYLANILINES - A MODIFIED FRIEDLANDER SYNTHESIS

被引：48

作者：

CHO, IS ^{[1
]}

GONG, LY ^{[1
]}

MUCHOWSKI, JM ^{[1
]}

机构：

[1] SYNTEX INC,INST ORGAN CHEM,3401 HILLVIEW AVE,PALO ALTO,CA 94304

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 26期

关键词：

D O I：

10.1021/jo00026a019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new variation of the Friedlander quinoline synthesis was devised based on the sequential reaction of ortho-lithiated N-t-Boc-anilines or N-pivaloylanilines with masked malondialdehyde derivatives [e.g., vinamidinium salts 1a and 1b, 3-(dimethylamino)acrolein (2), and 3-ethoxymethacrolein (3)] and subsequent acid-induced cyclization.

引用

页码：7288 / 7291

页数：4

共 22 条

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