SPONTANEOUS BACTERIAL PERITONITIS IS ASSOCIATED WITH HIGH-LEVELS OF INTERLEUKIN-6 AND ITS SECONDARY MEDIATORS IN ASCITIC FLUID

被引：44

作者：

PROPST, T ^{[1
]}

PROPST, A ^{[1
]}

HEROLD, M ^{[1
]}

SCHAUER, G ^{[1
]}

JUDMAIER, G ^{[1
]}

BRAUNSTEINER, H ^{[1
]}

STOFFLER, G ^{[1
]}

VOGEL, W ^{[1
]}

机构：

[1] UNIV INNSBRUCK, DEPT MICROBIOL, INNSBRUCK, AUSTRIA

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 12期

关键词：

CYTOKINES; LIVER CIRRHOSIS; SPONTANEOUS BACTERIAL PERITONITIS;

D O I：

10.1111/j.1365-2362.1993.tb00738.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated 37 patients with ascites and liver cirrhosis in order to examine whether on the basis of correlation of cytokines and acute phase proteins of the ascitic fluid, prognosis of spontaneous bacterial peritonitis can be made. Significantly enhanced levels of interleukin-6, as well as acute phase reactants alpha-1-antitrypsin and C-reactive protein were found in the ascitic fluid of patients with spontaneous bacterial peritonitis. The levels of tumour necrosis factor alpha (TNF-alpha), neopterin, interleukin 2-receptor and granulocyte-macrophage colony stimulating factor were higher in patients with spontaneous bacterial peritonitis, but without statistical significance, whereas no differences were found between the interferon gamma, interleukin-2 and interleukin-1 levels. In addition, interleukin-6, TNF-alpha and neopterin levels were found to correlate significantly with the outcome of the disease. These findings show that acute phase reaction occurs in the ascitic compartment in correlation with the development of spontaneous bacterial peritonitis.

引用

页码：832 / 836

页数：5

共 26 条

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