IMIDAZOL-1-YLALKANOATE ESTERS AND THEIR CORRESPONDING ACIDS - A NOVEL SERIES OF EXTRINSIC H-1-NMR PROBES FOR INTRACELLULAR PH

被引：28

作者：

GIL, MS

CRUZ, F

CERDAN, S

BALLESTEROS, P

机构：

[1] Univ Nacl Educ Distancia, FAC CIENCIAS, DEPT QUIM ORGAN & BIOL, E-28040 MADRID, SPAIN

[2] CSIC, INST INVEST BIOMED, E-28029 MADRID, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80463-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of extrinsic probes for intracellular pH (pH(i)) determination by H-1 NMR is described. Imidazol-1-ylacetate, malonate, 3-glutarate and 2-succinate esters were synthesized by reaction of imidazole either with alpha-bromoesters or with alpha,beta-unsaturated esters. The corresponding acids were prepared by hydrolysis.

引用

页码：1717 / 1722

页数：6

共 17 条

[1] 1,5-BIS-(N-BENZYL-N,N-DIETHYLAMMONIUM) DIETHYLETHER, DICHLORIDE (BBDE CL) - A NOVEL BIS-AMMONIUM SALT AS PHASE-TRANSFER CATALYST
ALVAREZBUILLA, J
VAQUERO, JJ
NAVIO, JLG
CABELLO, JF
SUNKEL, C
DECASAJUANA, MF
DORREGO, F
SANTOS, L
[J]. TETRAHEDRON, 1990, 46 (03) : 967 - 978
[2] THE SEPARATION OF PHOSPHOCREATINE FROM CREATINE, AND PH DETERMINATION IN FROG-MUSCLE BY NATURAL ABUNDANCE C-13-NMR
ARUS, C
CHANG, YC
BARANY, M
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 844 (01) : 91 - 93
[3] REACTIVITY OF AZOLES TOWARDS BENZALDEHYDE AND ITS DIMETHYLACETAL - SYNTHESIS OF N,N'-DIAZOLYLPHENYLMETHANES
BALLESTEROS, P
ELGUERO, J
CLARAMUNT, RM
[J]. TETRAHEDRON, 1985, 41 (24) : 5955 - 5963
[4] AKTIVIERUNG N-HALTIGER HETEROCYCLEN DURCH SILYLIERUNG
BIRKOFER, L
RICHTER, P
RITTER, A
[J]. CHEMISCHE BERICHTE-RECUEIL, 1960, 93 (12): : 2804 - 2809
[5] METABOLIC-REGULATION VIA INTRACELLULAR PH
BUSA, WB
NUCCITELLI, R
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (04): : R409 - R438
[6] COHEN R D, 1975, Critical Reviews in Clinical Laboratory Sciences, V6, P101, DOI 10.3109/10408367509151567
[7] REGULATION OF INTRACELLULAR PH BY HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AS MEASURED BY F-19 NMR
DEUTSCH, C
TAYLOR, JS
WILSON, DF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24): : 7944 - 7948
[8] GADIAN DG, 1982, NUCL MAGN RESON, P29
[9] HENDERSON RM, 1988, PH HOMEOSTASIS MECHA, P5
[10] ALKYLENEIMIDES .7. A NEW SYNTHESIS OF 2,7-NAPHTHYRIDINE DERIVATIVES
ISELIN, BM
HOFFMANN, K
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (12) : 3220 - 3222

← 1 2 →