IMIDAZOL-1-YLALKANOATE ESTERS AND THEIR CORRESPONDING ACIDS - A NOVEL SERIES OF EXTRINSIC H-1-NMR PROBES FOR INTRACELLULAR PH

被引：28

作者：

GIL, MS

CRUZ, F

CERDAN, S

BALLESTEROS, P

机构：

[1] Univ Nacl Educ Distancia, FAC CIENCIAS, DEPT QUIM ORGAN & BIOL, E-28040 MADRID, SPAIN

[2] CSIC, INST INVEST BIOMED, E-28029 MADRID, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80463-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of extrinsic probes for intracellular pH (pH(i)) determination by H-1 NMR is described. Imidazol-1-ylacetate, malonate, 3-glutarate and 2-succinate esters were synthesized by reaction of imidazole either with alpha-bromoesters or with alpha,beta-unsaturated esters. The corresponding acids were prepared by hydrolysis.

引用

页码：1717 / 1722

页数：6

共 17 条

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