QUANTAL ANALYSIS OF SUPPRESSING ACTION OF BACLOFEN ON MOSSY FIBER SYNAPSES IN GUINEA-PIG HIPPOCAMPUS

被引:23
作者
HIRATA, K [1 ]
SAWADA, S [1 ]
YAMAMOTO, C [1 ]
机构
[1] KANAZAWA UNIV,FAC MED,DEPT PHYSIOL,KANAZAWA,ISHIKAWA 920,JAPAN
关键词
GAMMA-AMINOBUTYRIC ACID; GAMMA-AMINOBUTYRIC ACIDB RECEPTOR; QUANTAL ANALYSIS; EXCITATORY POSTSYNAPTIC POTENTIAL; MOSSY FIBER; HIPPOCAMPUS;
D O I
10.1016/0006-8993(92)90226-Y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Baclofen, a selective agonist at the gamma-aminobutyric acid(B) (GABA(B)) receptor, has been considered to reduce the release of transmitter from nerve terminals by acting on presynaptic GABA(B) receptors, in addition to its postsynaptic action. The purpose of this study has been to re-examine quantitatively the action of baclofen in the hippocampus by a rigorous quantal analysis. (+/-)-Baclofen suppressed field potentials and intracellularly-recorded synaptic potentials induced in the subfield CA3 by mossy fiber stimulation in thin transverse sections of the guinea pig hippocampus. The amplitude distribution of excitatory postsynaptic potentials (EPSPs) induced monosynaptically by a granule cell could be described by the Pascal statistics. Suppression of the unitary EPSPs by baclofen (1 and 5-mu-M) was accompanied by decreases both in mean quantal content (m) and by mean quantal amplitude (q). The reduction in q was smaller than expected from a decrease in the input resistance of the postsynaptic neuron. It was suggested that the presynaptic and postsynaptic actions of baclofen contribute almost equally to suppression of the transmission at 1-mu-M, whereas the presynaptic action predominates at 5-mu-M.
引用
收藏
页码:33 / 40
页数:8
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