INVOLVEMENT OF D2 DOPAMINE-RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE OPIATE WITHDRAWAL SYNDROME

被引：189

作者：

HARRIS, GC ^{[1
]}

ASTONJONES, G ^{[1
]}

机构：

[1] HAHNEMANN UNIV,DEPT MENTAL HLTH SCI,DIV BEHAV NEUROBIOL,PHILADELPHIA,PA 19102

来源：

NATURE | 1994年 / 371卷 / 6493期

关键词：

D O I：

10.1038/371155a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE nucleus accumbens is prominently implicated in the reinforcing effects of abused drugs(1-4), and is an important site for mediating aversive stimulus properties of opiate withdrawal(5). It is generally thought, however, that the role of the accumbens is negligible in the somatic signs of opiate withdrawal(5-7). Contrary to this assumption, we now report that D2 dopaminergic receptor activity in the accumbens area potently regulates somatic symptoms of opiate withdrawal. We find that activation of D2 receptors within the accumbens prevents somatic signs of naloxone-induced opiate withdrawal and, conversely, that blockade of accumbal D2 receptors in opiate-dependent animals elicits somatic withdrawal symptoms. These data indicate that dopamine in the accumbens not only is important in the rewarding effects of abused drugs, but also (via D2 receptors) plays a pivotal role in opiate withdrawal.

引用

页码：155 / 157

页数：3

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