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B-HT-920 IS A FULL AGONIST AT BOTH PRESYNAPTIC AND POSTSYNAPTIC D-2 DOPAMINE-RECEPTORS

被引：23
作者：
ANDEN, NE
GRABOWSKAANDEN, M
机构：
[1] Department of Pharmacology, Karolinska Institutet, Stockholm
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1990年 / 79卷 / 03期
关键词：
apomorphine; B-HT920; D-2; receptors;
D O I：
10.1007/BF01245131
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Stimulation of presynaptic D-2 dopamine receptors by B-HT 920 or by apomorphine inhibited the synthesis of dopamine in the corpus striatum of gammabutyrolactone-treated mice to about the same extent. Stimulation of postsynaptic D-2 dopamine receptors by B-HT 920 given in combination with the D-1 receptor agonist SKF38393 enhanced the motor activity of reserpinetreated mice at least as much as observed following the combined D-1/D-2 receptor agonist apomorphine. Since B-HT 920 is as effective as apomorphine in these models, B-HT 920 appears to be a full agonist at both pre- and postsynaptic D-2 dopamine receptors. © 1990 Springer-Verlag.
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页码：209 / 214
页数：6
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