The enzymatic synthesis and ant HIV-1 activity of 9-beta-D-2 ',3 '-dideoxynucleosides of N(6)-substituted purines

被引：6

作者：

Betbeder, D. ^{[1
]}

Hutchinson, D. W. ^{[1
]}

Richards, A. O'L ^{[1
]}

Mahood, N. ^{[2
]}

Kinchington, D. ^{[3
]}

机构：

[1] Warwick Univ, Chem Dept, Coventry CV4 7AL, W Midlands, England

[2] Med Res Council Collaborat Ctr, London NW7 1AD, England

[3] St Marys Hosp, Med Sch, Dept Med Microbiol, Div Virol, London WC2 1PG, England

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1990年 / 1卷 / 04期

关键词：

D O I：

10.1177/095632029000100404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9-beta-D-2',3'-dideoxyribonucleosides of four N(6)-substituted purines and 1-deazapurine were prepared using crude nucleoside N-deoxyribosyltransferases (EC 2.4.2.6) from Lactobacillus leichmannii. The 2',3'-dideoxynucleosides derived from N(6)-substituted purines (1-4) are inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1), with EC90 values in the range 20-100 and 20-200 mu m, depending on the cell line used, and have low in vitro toxicity at their effective concentrations.

引用

页码：249 / 253

页数：5

共 17 条

[11] 3'-AZIDO-3'-DEOXYTHYMIDINE (BW A509U) - AN ANTIVIRAL AGENT THAT INHIBITS THE INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS INVITRO [J].

MITSUYA, H ;

WEINHOLD, KJ ;

FURMAN, PA ;

STCLAIR, MH ;

LEHRMAN, SN ;

GALLO, RC ;

BOLOGNESI, D ;

BARRY, DW ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7096-7100

[12] RAPID AND AUTOMATED TETRAZOLIUM-BASED COLORIMETRIC ASSAY FOR THE DETECTION OF ANTI-HIV COMPOUNDS [J].

PAUWELS, R ;

BALZARINI, J ;

BABA, M ;

SNOECK, R ;

SCHOLS, D ;

HERDEWIJN, P ;

DESMYTER, J ;

DECLERCQ, E .

JOURNAL OF VIROLOGICAL METHODS, 1988, 20 (04) :309-321

[13] THE TOXICITY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

RICHMAN, DD ;

FISCHL, MA ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

HIRSCH, MS ;

JACKSON, GG ;

DURACK, DT ;

NUSINOFFLEHRMAN, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :192-197

[14] PURINES .1. THE CHLORINATION OF CERTAIN PURINONES WITH PHOSPHOROUS OXYCHLORIDE IN THE PRESENCE OF ALIPHATIC TERTIARY AMINES [J].

ROBINS, RK ;

CHRISTENSEN, BE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (14) :3624-3627

[15] REACTIONS OF 2-ACYLOXYISOBUTYRYL HALIDES WITH NUCLEOSIDES .2. REACTIONS OF ADENOSINE [J].

RUSSELL, AF ;

GREENBERG, S ;

MOFFATT, JG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (12) :4025-4030

[16] PRODUCTION OF 2',3'-DIDEOXYADENOSINE AND 2',3'-DIDEOXYINOSINE FROM 2',3'-DIDEOXYURIDINE AND THE CORRESPONDING PURINE-BASES BY RESTING CELLS OF ESCHERICHIA-COLI AJ-2595 [J].

SHIRAE, H ;

KOBAYASHI, K ;

SHIRAGAMI, H ;

IRIE, Y ;

YASUDA, N ;

YOKOZEKI, K .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (02) :419-424

[17] SYNTHESIS OF 2',3'-DIDEOXYURIDINE VIA DEOXYGENATION OF 2',3'-O-(METHOXYMETHYLENE)URIDINE [J].

SHIRAGAMI, H ;

IRIE, Y ;

SHIRAE, H ;

YOKOZEKI, K ;

YASUDA, N .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (21) :5170-5173

← 1 2 →