Assessment of bone vascularization and its role in bone remodeling

被引：110

作者：

Lafage-Proust, Marie-Helene ^{[1
,2
]}

Roche, Bernard ^{[1
,2
]}

Langer, Max ^{[2
,3
]}

Cleret, Damien ^{[1
,2
]}

Vanden Bossche, Arnaud ^{[1
,2
]}

Olivier, Thomas ^{[2
,4
]}

Vico, Laurence ^{[1
,2
]}

机构：

[1] INSERM, U1059, Lab Biol Integree Tissu Osseux, F-42023 St Etienne, France

[2] Univ Lyon, Lyon, France

[3] CNRS, UMR 5220, INSERM, U1044,CREATIS, Lyon, France

[4] Lab Hubert Curien, St Etienne, France

来源：

BONEKEY REPORTS | 2015年 / 4卷

关键词：

D O I：

10.1038/bonekey.2015.29

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Bone is a composite organ that fulfils several interconnected functions, which may conflict with each other in pathological conditions. Bone vascularization is at the interface between these functions. The roles of bone vascularization are better documented in bone development, growth and modeling than in bone remodeling. However, every bone remodeling unit is associated with a capillary in both cortical and trabecular envelopes. Here we summarize the most recent data on vessel involvement in bone remodeling, and we present the characteristics of bone vascularization. Finally, we describe the various techniques used for bone vessel imaging and quantitative assessment, including histology, immunohistochemistry, microtomography and intravital microscopy. Studying the role of vascularization in adult bone should provide benefits for the understanding and treatment of metabolic bone diseases.

引用

页数：8

共 76 条

[1]

Preferential activity of Tie2 promoter in arteriolar endothelium [J].